Phototactic guidance of a tissue-engineered soft-robotic ray-Reference-Cited by-同舟云学术

Phototactic guidance of a tissue-engineered soft-robotic ray

Published:2016-07-08 Issue:6295 Volume:353 Page:158-162
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Park Sung-Jin¹,Gazzola Mattia²,Park Kyung Soo³⁴,Park Shirley⁵,Di Santo Valentina⁶,Blevins Erin L.⁶,Lind Johan U.¹,Campbell Patrick H.¹,Dauth Stephanie¹,Capulli Andrew K.¹,Pasqualini Francesco S.¹,Ahn Seungkuk¹,Cho Alexander¹,Yuan Hongyan¹,Maoz Ben M.¹,Vijaykumar Ragu⁵,Choi Jeong-Woo³⁴,Deisseroth Karl⁵⁷,Lauder George V.⁶,Mahadevan L.²⁸,Parker Kevin Kit¹⁴

Affiliation:

1. Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

2. John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.

3. Department of Chemical and Biomolecular Engineering, Sogang University, Seoul 121-742, Korea.

4. Sogang-Harvard Research Center for Disease Biophysics, Sogang University, Seoul 121-742, Korea.

5. Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.

6. Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138, USA.

7. Department of Psychiatry and Behavioral Sciences and the Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.

8. Department of Organismic and Evolutionary Biology, Department of Physics, Wyss Institute for Biologically Inspired Engineering, Kavli Institute for Nanobio Science and Technology, Harvard University, Cambridge, MA 02138S, USA.

Abstract

Swim into the light A bio-inspired swimming robot that mimics a ray fish can be guided by light. Park et al. built a 1/10th-scale version of a ray fish with a microfabricated gold skeleton and a rubber body powered by rat heart muscle cells. The cardiomyocytes were genetically engineered to respond to light cues, so that the undulatory movements propelling the robot through water would follow a light source. Science , this issue p. 158

Funder

Harvard Paulson School of Engineering and Applied Sciences

Wyss Institute for Biologically Inspired Engineering

National Center for Advancing Translational Sciences

National Science Foundation (NSF)

NSF Materials Research Science and Engineering Center

Office of Naval Research Multidisciplinary University Research Initiative

Swiss National Science Foundation

MacArthur Foundation

Radcliffe Institute

National Research Foundation of Korea

U.S. Army Research Laboratory and Office