Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies-Reference-Cited by-同舟云学术

Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies

Published:2021-02-26 Issue:6532 Volume:371 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Chang Che-Wei¹^ORCID,Shao Eric¹^ORCID,Mucke Lennart¹²^ORCID

Affiliation:

1. Gladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA 94158, USA.

2. Department of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, CA 94158, USA.

Abstract

The many faces of tau The protein tau is implicated in several brain disorders, including Alzheimer's disease, suggesting that it could be a target of therapeutics. However, because it is unclear how the pleiotropic roles of tau lead to neural pathology in different brain diseases, drug development remains challenging. Chang et al. review the possible mechanisms of tau in brain diseases and possible paths forward to improving research and drug development. Science , this issue p. eabb8255

Funder

National Institutes of Health

Alzheimer's Association

Tau Consortium

Cure Network Dolby Acceleration Partners

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference150 articles.

1. Tau in physiology and pathology

2. Single-molecule tracking of tau reveals fast kiss-and-hop interaction with microtubules in living neurons