Bergmann Glial AMPA Receptors Are Required for Fine Motor Coordination-Reference-Cited by-同舟云学术

Bergmann Glial AMPA Receptors Are Required for Fine Motor Coordination

Published:2012-08-10 Issue:6095 Volume:337 Page:749-753
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Saab Aiman S.¹²,Neumeyer Alexander³,Jahn Hannah M.¹²,Cupido Alexander¹,Šimek Antonia A. M.⁴,Boele Henk-Jan⁴,Scheller Anja¹²,Le Meur Karim¹,Götz Magdalena⁵⁶,Monyer Hannah⁷,Sprengel Rolf⁸,Rubio Maria E.⁹,Deitmer Joachim W.³,De Zeeuw Chris I.⁴¹⁰,Kirchhoff Frank¹²

Affiliation:

1. Department of Molecular Physiology, University of Saarland, Homburg, Germany.

2. Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Göttingen, Germany.

3. Fachbereich Biologie, Technische Universität Kaiserslautern, Kaiserslautern, Germany.

4. Department of Neuroscience, Erasmus MC, Rotterdam, Netherlands.

5. Department of Physiology, Ludwig-Maximilians University, Munich, Germany.

6. Institute for Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany.

7. Department of Clinical Neurobiology at the German Cancer Research Center and the Medical Faculty of the Heidelberg University, Heidelberg, Germany.

8. Department of Molecular Neurobiology, Max Planck Institute of Medical Research, Heidelberg, Germany.

9. Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA, USA.

10. Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences (KNAW), Amsterdam, Netherlands.

Abstract

Crucial Cerebellar Glial Cells The role of glial cells and their interaction with neurons in normal behavior is unclear. To address this question, Saab et al. (p. 749 , published online 5 July) studied a special type of glial cell in the cerebellum. Conditional mutant mice were produced in which the two glutamate receptor subunits normally present in Bergmann glial cells were efficiently ablated in a temporally controlled manner. Glutamate signaling of the glial cells contributed to the structural and functional integrity of the cerebellar network. Bergmann glial cells also played a role in the “fine-tuning” of neuronal processing, which is crucial for the fast and precise control of complex motor behavior.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference34 articles.

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