βCaMKII in Lateral Habenula Mediates Core Symptoms of Depression-Reference-Cited by-同舟云学术

βCaMKII in Lateral Habenula Mediates Core Symptoms of Depression

Published:2013-08-30 Issue:6149 Volume:341 Page:1016-1020
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Li Kun¹²,Zhou Tao¹²,Liao Lujian³,Yang Zhongfei¹,Wong Catherine³,Henn Fritz⁴,Malinow Roberto⁵,Yates John R.³,Hu Hailan¹

Affiliation:

1. Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, P. R. China.

2. Graduate School of Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, P. R. China.

3. The Scripps Research Institute, Department of Molecular and Cellular Neurobiology, La Jolla, CA 92037, USA.

4. Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

5. University of California at San Diego, La Jolla, CA, 92093, USA.

Abstract

Depression and the Habenula The lateral habenula (LHb) appears to have a role in depression. However, the underlying mechanisms are poorly understood, and by using multiple rodent models of depression, Li et al. (p. 1016 ) identified a signaling pathway and associated neuronal adaptations in which the enzyme βCaMKII was selectively up-regulated in the LHb. Manipulations that enhanced βCaMKII levels increased depression-related phenotypes, and RNA interference of CaMKIIb blunted depression. Enhanced βCaMKII levels in the habenula promoted excitatory synaptic transmission on these neurons and increased action potential firing mediated by an up-regulation of a specific subtype of glutamate receptors.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference53 articles.

1. D. S. Charney E. J. Nestler Neurobiology of Mental Illness (Oxford Univ. Press New York 2005).

2. Depression – emerging insights from neurobiology

3. Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatment

4. Dopamine agonists and stress produce different patterns of Fos-like immunoreactivity in the lateral habenula

5. Lateral habenula as a source of negative reward signals in dopamine neurons

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