Product-to-Parent Reversion of Trenbolone: Unrecognized Risks for Endocrine Disruption-Reference-Cited by-同舟云学术

Product-to-Parent Reversion of Trenbolone: Unrecognized Risks for Endocrine Disruption

Published:2013-10-18 Issue:6156 Volume:342 Page:347-351
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Qu Shen¹,Kolodziej Edward P.²,Long Sarah A.³,Gloer James B.³,Patterson Eric V.⁴,Baltrusaitis Jonas⁵⁶,Jones Gerrad D.²,Benchetler Peter V.²,Cole Emily A.²,Kimbrough Kaitlin C.²,Tarnoff Matthew D.¹,Cwiertny David M.¹⁷

Affiliation:

1. Department of Civil and Environmental Engineering, University of Iowa, 4105 Seamans Center for the Engineering Arts and Sciences, Iowa City, IA 52242–1527, USA.

2. Department of Civil and Environmental Engineering, University of Nevada, Reno, Mail Stop 258, Reno, NV 89557, USA.

3. Department of Chemistry, University of Iowa, Iowa City, IA 52242–1527, USA.

4. Department of Chemistry, Truman State University, Kirksville, MO 63501, USA

5. PhotoCatalytic Synthesis Group, MESA+ Institute for Nanotechnology, Faculty of Science and Technology, University of Twente, Meander 225, Post Office Box 217, 7500 AE Enschede, Netherlands.

6. Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, IA 52242, USA.

7. Department of Chemical and Biochemical Engineering, University of Iowa, 4133 Seamans Center for the Engineering Arts and Sciences, Iowa City, IA 52242–1527, USA.

Abstract

Return of the Steroid Trace levels of organic contaminants enter aquatic ecosystems from a variety of sources, including runoff of from agricultural lands. When these compounds and their metabolites break down, it is generally assumed that they become inert and pose less ecological risk. Qu et al. (p. 347 , published online 26 September) tracked the sunlight-mediated transformation of metabolites of trenbolone acetate (TBA)—a common growth-promoting steroid given to beef cattle—across a number of conditions in the laboratory and in the field. When the degradation products were exposed to dark conditions following photodegradation, they surprisingly reverted back to TBA metabolites, including analog steroidal compounds similar to TBA with unknown biological effects.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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