Comment on “Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals”-Reference-Cited by-同舟云学术

Comment on “Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals”

Published:2023-03-10 Issue:6636 Volume:379 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Herai Roberto H.¹^ORCID,Semendeferi Katerina²^ORCID,Muotri Alysson R.³^ORCID

Affiliation:

1. Neurogenetics and Bioinformatics Laboratory, Experimental Multiuser Laboratory (LEM), Graduate Program in Health Sciences, School of Medicine and Life Sciences, Pontifícia Universidade Católica do Paraná, Curitiba, PR 80215-901, Brazil.

2. Department of Anthropology, Center for Academic Research and Training in Anthropogeny (CARTA), Archealization Center (ArchC), University of California, San Diego, La Jolla, CA 92037, USA.

3. Department of Pediatrics and Department of Cellular & Molecular Medicine, School of Medicine, Center for Academic Research and Training in Anthropogeny (CARTA), Kavli Institute for Brain and Mind, Archealization Center (ArchC), University of California, San Diego, La Jolla, CA 92037, USA.

Abstract

Pinson et al . ( 1 ) concluded that the modern human TKTL1 gene is responsible for an increased number of cortical neurons. We show that the “putative Neanderthal variant” of TKTL1 is present in modern human backgrounds. We dispute their argument that this genetic variant is responsible for brain differences in modern humans as opposed to Neanderthals.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Link

https://www.science.org/doi/pdf/10.1126/science.adf0602

Reference13 articles.

1. Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals

2. Exploring human genomic diversity with gnomAD

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4. The complete genome sequence of a Neanderthal from the Altai Mountains

5. Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment

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