Differential regulation of mTORC1 by leucine and glutamine-Reference-Cited by-同舟云学术

Differential regulation of mTORC1 by leucine and glutamine

Published:2015-01-09 Issue:6218 Volume:347 Page:194-198
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Jewell Jenna L.¹,Kim Young Chul¹,Russell Ryan C.¹,Yu Fa-Xing²,Park Hyun Woo¹,Plouffe Steven W.¹,Tagliabracci Vincent S.¹,Guan Kun-Liang¹

Affiliation:

1. Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA.

2. Children's Hospital and Institute of Biomedical Sciences, Fudan University, Shanghai 200032, China.

Abstract

Getting specific about amino acid sensing The protein kinase complex mTORC1 regulates growth and metabolism, and its activity is controlled in response to the abundance of cellular amino acids. Jewell et al. report that control of mTORC1 in response to glutamine does not require the Rag guanosine triphosphatase (GTPase) implicated in the sensing of other amino acids such as leucine (see the Perspective by Abraham). For sensing of glutamine, another GTPase, Arf1, was required. Distinct mechanisms thus appear to couple various amino acids to signaling by the mTORC1 complex. Science , this issue p. 194 ; see also p. 128

Funder

NIH

Department of Defense

The Hartwell Foundation

Canadian Institutes of Health Research

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference35 articles.

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