Pregnenolone Can Protect the Brain from Cannabis Intoxication-Reference-Cited by-同舟云学术

Pregnenolone Can Protect the Brain from Cannabis Intoxication

Published:2014-01-03 Issue:6166 Volume:343 Page:94-98
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Vallée Monique¹²,Vitiello Sergio¹²,Bellocchio Luigi¹²,Hébert-Chatelain Etienne¹²,Monlezun Stéphanie³,Martin-Garcia Elena⁴,Kasanetz Fernando¹²,Baillie Gemma L.⁵,Panin Francesca¹²,Cathala Adeline¹²,Roullot-Lacarrière Valérie¹²,Fabre Sandy³,Hurst Dow P.⁶,Lynch Diane L.⁶,Shore Derek M.⁶,Deroche-Gamonet Véronique¹²,Spampinato Umberto¹²,Revest Jean-Michel¹²,Maldonado Rafael⁴,Reggio Patricia H.⁶,Ross Ruth A.⁵,Marsicano Giovanni¹²,Piazza Pier Vincenzo¹²

Affiliation:

1. INSERM, Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, U862, F-33000 Bordeaux, France.

2. Université de Bordeaux, Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, U862, F-33000 Bordeaux, France.

3. Alienor Farma Parc Scientifique Unitec1, 2 Allée du Doyen Georges Brus, 33600 Pessac, France.

4. Laboratory of Neuropharmacology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Parc de Recerca Biomédica de Barcelona, Calle Dr. Aiguader 88, Barcelona 08003, Spain.

5. Kosterlitz Centre for Therapeutics, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, UK.

6. Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA.

Abstract

Counteracting Cannabis What is the role of steroid hormones in vulnerability to addiction? Working with rodents, Vallée et al. (p. 94 ) found that all major drugs of abuse (morphine, cocaine, alcohol, nicotine) increase neurosteroid levels, with the active ingredient in cannabis (THC) inducing a particularly large increase. THC and other drugs increased levels of pregnenolone, long thought to be an inactive precursor of downstream active steroids. Pregnenolone antagonized most of the known behavioral and somatic effects of THC.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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