Glycerophospholipid regulation of modality-specific sensory axon guidance in the spinal cord-Reference-Cited by-同舟云学术

Glycerophospholipid regulation of modality-specific sensory axon guidance in the spinal cord

Published:2015-08-28 Issue:6251 Volume:349 Page:974-977
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Guy Adam T.¹,Nagatsuka Yasuko¹,Ooashi Noriko¹,Inoue Mariko¹,Nakata Asuka¹,Greimel Peter¹²,Inoue Asuka³⁴,Nabetani Takuji¹,Murayama Akiho⁵,Ohta Kunihiro⁵,Ito Yukishige⁶,Aoki Junken³⁷,Hirabayashi Yoshio¹,Kamiguchi Hiroyuki¹

Affiliation:

1. RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

2. Lipid Biology Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

3. Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Sendai, Miyagi 980-8578, Japan.

4. Japan Science and Technology Agency, Precursory Research for Embryonic Science and Technology (PRESTO), 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan.

5. Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, 3-8-1 Komaba, Meguro, Tokyo 153-8902, Japan.

6. Synthetic Cellular Chemistry Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

7. Japan Agency for Medical Research and Development, Core Research for Evolutional Science and Technology (AMED-CREST), 1-7-1 Otemachi, Chiyoda, Tokyo 100-0004, Japan.

Abstract

Axon paths in developing spinal cords Sensory neurons entering the spinal cord take different paths as inputs for pain and proprioception diverge. Working with chick and mouse embryos, Guy et al. found that glycerophospholipids produced by radial glial cells guide these neural fibers, or axons, in the developing spinal cord. A soluble glycerophospholipid released by the cells provided an inhibitory signal to the pain-sensitive axons, keeping them on their own unique pathway. Science , this issue p. 974

Funder

Mizutani Foundation for Glycoscience

Ministry of Education, Culture, Sports, Science and Technology (MEXT)

Japan Society for the Promotion of Science Foreign Postdoctoral Fellowships

AMED-CREST

PRESTO

Naito Foundation Subsidy for Promotion of Specific Research Projects

Platform for Dynamic Approaches to Living System

Scientific Research on Innovative Areas

Publisher

American Association for the Advancement of Science (AAAS)

Subject