GABA Effects on Neurogenesis: An Arsenal of Regulation

Author:

Yuan Ti-Fei1

Affiliation:

1. The author is a graduate student in the Department of Anatomy, The University of Hong Kong, Li Kai Shing Faculty of Medicine, 21 Sassoon Road, Hong Kong.

Abstract

The well-known inhibitory neurotransmitter GABA is excitatory to immature neurons during development as well as to neural progenitor cells during adult neurogenesis. Recent evidence indicates that GABA plays a role in regulating neurogenesis in various situations. This journal club paper aims to provide a skeleton description of GABA regulation of neurogenesis, describing some of the disparate mechanisms and scenarios in which it is involved.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference27 articles.

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2. J. L. Barker, T. Behar, Y. X. Li, Q. Y. Liu, W. Ma, D. Maric, I. Maric, A. E. Schaffner, R. Serafini, S. V. Smith, R. Somogyi, J. Y. Vautrin, X. L. Wen, H. Xian, GABAergic cells and signals in CNS development. Perspect. Dev. Neurobiol. 5, 305–322 (1998).9777645

3. Excitatory actions of gaba during development: the nature of the nurture

4. Is there more to gaba than synaptic inhibition?

5. GABA regulates synaptic integration of newly generated neurons in the adult brain

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