Affiliation:
1. Center for Neuroscience and Department of Neurology, University of California, Davis, CA, 95616
Abstract
In ClC chloride (Cl
–
) channels, unlike cation-selective ion channels, ion permeation is intimately coupled to fast gating. Recent research comparing the crystallographic structure of a bacterial ClC channel with functional studies of a
Torpedo
ClC channel suggests that gating depends on the negatively charged carboxyl group on a glutamate residue, which blocks the channel pore. In this model, the permeating Cl
–
competes with the carboxyl group for an anion-binding site in the channel pore. This model of Cl
–
competition with a glutamate gate helps explain the effect of intracellular Cl
–
on channel gating; the mechanism underlying the effects of extracellular Cl
–
, however, remains to be determined, as does the nature of the Cl
–
channel slow gate.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
18 articles.
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