Regulation of Enzymatic Activity and Gene Expression by Membrane Fluidity

Author:

Los Dmitry A.12,Murata Norio12

Affiliation:

1. D. A. Los is at the Institute of Plant Physiology, Russian Academy of Sciences, Botanicheskaya Street 35, 127276 Moscow, Russia.

2. N. Murata is at the National Institute for Basic Biology, Okazaki 444, Japan.

Abstract

Changes in the cellular environment can lead to alterations in the fluidity of the membranes of prokaryotes and eukaryotes. Changes in temperature and osmotic conditions are two of the best-studied stresses that can affect membrane fluidity. Los and Murata discuss the types of sensors that detect these changes in membrane fluidity and the types of signals that are generated.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference20 articles.

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3. Sukharev, S. (1999) Mechanosensitive channels in bacteria as membrane tension reporters. FASEB J. 13 (suppl.): S55-61.

4. Maeda, M., Wurgler-Murphy, S.M., and Saito, H. (1994) A two-component system that regulates an osmosensing MAP kinase cascade in yeast. Nature 309: 242-245.

5. Transmembrane Signal Transduction and Osmoregulation in Escherichia coli: II. The Osmotic Sensor, EnvZ, Located in the Isolated Cytoplasmic Membrane Displays Its Phosphorylation and Dephosphorylation Abilities as to the Activator Protein, OmpR1

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