Water Clear Cell Parathyroid Adenoma: A Report of Two Cases

Abstract

Primary hyperparathyroidism is a disease characterized by hypercalcemia and excessive production of parathyroid hormone. It is the most common cause of hypercalcemia in outpatient practice and the third common endocrine disorder. The incidence of primary hyperparathyroidism is increasing with age, and it is more common in women than in men. 80-85% of cases of primary hyperparathyroidism are due to single parathyroid adenoma. The majority of parathyroid adenomas contain a mixed cell population with predominance of chief cells. Primary hyperparathyroidism with clear cell adenoma is very rare. Here we are sharing two cases of water clear cell parathyroid adenoma associated with primary hyperparathyroidism presented with deferent clinical manifestations.