Dynamics of leukocyte inflammatory markers in patients with ST-elevation myocardial infarction depending on left ventricle ejection fraction

Abstract

Aim: to evaluate the dynamics of leukocyte inflammatory markers in patients with ST-elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI) depending on ejection fraction of left ventricular (LV). Material and methods. The study group consisted of 23 consecutive patients with STEMI admitted to the Regional Clinical Cardiology Center in Chernivtsi, who underwent successful reperfusion treatment by PCI. To evaluate inflammatory markers, a complete blood count (CBC) was assessed at admission, and on day 10 of hospital stay on the background of optimal drug therapy. Results. It was found that patients with STEMI and reduced left ventricular ejection fraction (LVEF) (group 2) at admission had a significantly higher leukocyte count (P < 0.05) and an increase in the absolute neutrophils (P < 0.01) with significantly higher inflammatory markers: neutrophil-to-lymphocyte ratio (NLR) (P < 0.01), monocyte-to-lymphocyte ratio (MLR), systemic immune inflammation index (SII) (P < 0.01), systemic inflammation response index (SIRI) (P < 0.01), aggregate index of systemic inflammation (AISI) (P < 0.05), and integrated index of inflammation (III) (P < 0.05). On day 10 of treatment, the analysis of inflammatory markers showed that in patients of group 2, NLR (P < 0.01) and SII (P < 0.05) remained significantly higher than in STEMI patients with preserved LVEF (group 1). At the study of the changes in leukocyte-based inflammatory markers in STEMI patients under the influence of optimal drug therapy after PCI, a decrease (P < 0.05) in NLR, MLR, SII, SIRI, IIII, and an increase in (P < 0.05) LMR were observed. Conclusions. CBC of inflammatory markers at admission identifies the risk of adverse cardiovascular events and determines measures to regulate the activity of the inflammatory process in STEMI.