Determination of the temporary disability duration in patientswith acute myocardial infarction depending on the body mass index

Abstract

Prolonged temporary disability in patients with acute myocardial infarction (AMI) is more common in the presence of concomitant abnormalities. Adipokine C1q/TNF-related protein 3 (CTRP-3) is produced by adipose tissue and exhibits anti-inflammatory and cardioprotective properties. The course and prognosis of AMI depend on the presence of comorbid disorders and hence are objects of scientific interest. Aim. To identify risk factors affecting the temporary disability duration in AMI patients depending on body mass index (BMI). Materials and methods. The study involved 189 patients with ST-segment elevation AMI who were divided into 3 groups depending on BMI. The first group included 60 patients with AMI and normal BMI, the second group comprised 68 patients with AMI and excess body weight (EBW) and the third group was composed of 61 AMI patients with obesity. CTRP-3 was determined by enzyme-linked immunosorbent assay. Statistical data were processed using the licensed software package IBM SPPS Statistics (version 27.0). Significance of differences between normally distributed mean values of quantitative variables was assessed by ANOVA with Bonferroni correction for multiple comparisons. The logistic regression method was used to determine the period of temporary disability. The difference was considered significant at a P value ˂ 0.05. Results. In analyzing the studied indicators, a significant decrease in the concentration of CTRP-3 was found in AMI patients with obesity on the first day compared to AMI patients with normal BMI (P < 0.001), which indicated the effect of obesity on the AMI development. The following indicators were determined to construct a model for predicting the duration of temporary disability, namely CTRP-3 on day 1, glucose on day 1, the presence of permanent atrial fibrillation, early complicationsof AMI. Conclusions. The proposed method helped to determine the duration of temporary disability in patients with AMI depending on BMI, which would improve the provision of high-quality diagnostics and treatment of patients by reducing the economic costs of the length of hospital stay.