Features of the reactivity of cerebral energy metabolism in patients with vibration disease of various etiogenesis

Abstract

Introduction. A comparative assessment of the reactivity of cerebral energy metabolism (CEM) under stress will allow us to determine the features of the course of vibration disease (VD) caused by exposure to various types of vibration. The study aims to consider the features of the reactivity of the cerebral energy metabolism (CEM) in patients with vibration disease, depending on the type of vibration exposure. Materials and methods. The researchers studied the features of adaptation under stress using the method of neuroenergetic mapping (NEM) with measurement of the level of constant potential (LCP). Groups were formed: I (n=58) — patients with VD due to the effects of local vibration (VDloc), II (n=50) — with VD associated with the combined effects of local and general vibration (VDcomb), III (n=39) — a comparison group. Results. The authors found that for patients with VDloc and VDcomb it is characterized by a rapid rigid reaction to physical and emotional stress. In patients with VD, regardless of the type of vibration exposure, there was a predominance of negative reactions of cerebral energy metabolism to physical activity compared with emotional activity. The restoration of cerebral energy metabolism in the post-hyperventilation period in the predominant number of patients has a disorder of autonomic autoregulation of the constancy of internal functions, which creates equal risks of the formation of comorbid pathology in both VDloc and VDcomb. Limitations. The study is limited to a sample of patients, an integrated approach based on modern diagnostic methods, and the use of multidimensional exploratory analysis methods. Conclusion. The results obtained substantiate the independence of the adaptive reactivity of cerebral energy metabolism from the type of vibration exposure and indicate the predominance of a rigid reaction variant characterizing the disorder of adaptive reactions according to the asthenic type. Ethics. The examination of patients was conducted in accordance with the ethical standard of the Helsinki Declaration of the World Medical Association "Ethical Principles of conducting scientific medical research with human participation" as amended in 2000 and the "Rules of Good Clinical Practice" (approved by Order of the Ministry of Health of the Russian Federation No. 200n on 04/01/2016). All the surveyed signed an informed consent to participate in the study. There is a conclusion of the local Ethics Committee (Protocol No. 5 dated 03/21/2023).