Clinical and experimental studies of cardiovascular disorders in the conditions of fluoride intoxication of the body

Abstract

Introduction. Th e aluminum industry occupies one of the leading positions among other branches of non-ferrous metallurgy in terms of the prevalence of occupational pathology, many questions of pathophysiological mechanisms of its development remain open. Among the concomitant somatic diseases in workers engaged in the production of aluminum, the fi rst place is occupied by the pathology of the cardiovascular system against the background of chronic fl uoride intoxication of the body.The aim of the study is to identify some features of the formation of cardiovascular pathology in the conditions of prolonged exposure to high doses of fl uorides on the body. Materials and methods. A complex analysis of the prevalence of cardiovascular pathology and specifi c features of the pathogenesis of arterial hypertension, coronary heart disease and atherosclerosis was performed based on clinical and genetic research methods in 246 workers with fl uorosis and in the comparison group (106 people). Experimental studies of the morphofunctional state of the myocardium and blood vessels in conditions of chronic fl uoride exposure with histological analysis of tissues were performed on white laboratory rats.Results. In the clinical pilot study with the assessment of pathological disorders of the cardiovascular system in terms of fl uoride intoxication revealed the structure and frequency of cardiovascular disease metallurgists main and auxiliary workers, employed in the production of aluminium. Th e Association of VEGF, IL1β, GSTT 1, GSTM1,  СYP1А1, CYP1A2 genes with concomitant coronary, obliterating and multifocal atherosclerosis, heart rhythm disorders, arterial hypertension, coronary heart disease complicated by pyelonephritis and liver steatosis was determined. Th e experiment shows the toxic eff ect of fl uoride on the myocardium and coronary vessels.Conclusions. In the ranking structure of professionally determined morbidity in workers engaged in the production of aluminum, cardiovascular pathology prevails, in particular, arterial hypertension, coronary heart disease, atherosclerosis against the background of pronounced multi-organ manifestations, violations of bone metabolism, confi rmed by experimental data.