Affiliation:
1. Key Laboratory of Infectious Disease and Biosafety, Guizhou Provincial Department of Education, Zunyi Medical University, Zunyi, Guizhou, China
Abstract
Among several existing mouse models for hepatitis B virus (HBV) infection, the high-pressure hydrodynamic injection (HDI) method is frequently used in HBV research due to its economic advantages and ease of implementation. The use of the HDI method is influenced by factors such as mouse
genetic background, age, sex, and the type of HBV plasmid used. This overview provides a multidimensional analysis and comparison of various factors that influence the effectiveness of the HBV mouse model established through HDI. The goal is to provide a summary of information for researchers
who create HBV models in mice.
Publisher
American Association for Laboratory Animal Science