Effects of Exogenous Erythropoietin on Rabbit (<i>Oryctolagus cuniculus</i>) Hematological and Biochemical Parameters-Reference-Cited by-同舟云学术

Effects of Exogenous Erythropoietin on Rabbit (Oryctolagus cuniculus) Hematological and Biochemical Parameters

Published:2023-12-01 Issue:6 Volume:73 Page:439-445
ISSN:1532-0820
Container-title:Comparative Medicine
language:en
Short-container-title:comp med

Author:

Levine Jessica K¹,Seixas Josilene Nascimento²,Ritter Jana M²,Liew Amanda Y³,Tansey Cassandra M¹

Affiliation:

1. Comparative Medicine Branch, Division of Scientific Resources, Centers for Disease Control and Prevention, Atlanta, Georgia

2. Infectious Disease Pathology Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia

3. National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

Abstract

Rabbits can develop anemia due to serial phlebotomy or secondary to induced disease states. This study evaluated the effects of a single injection and three consecutive injections of erythropoietin in rabbits at 150 IU/kg and 1,000 IU/kg in order to determine whether these dosages produce a sustained increase in hematocrit. Analysis of CBC and chemistry parameters showed significant elevation in hematocrit one week after administration of 1,000 IU/kg erythropoietin for three consecutive days. These results indicate that this dosage regimen can increase hematocrit in apparently healthy, nonanemic rabbits for one week.

Publisher

American Association for Laboratory Animal Science

Subject

General Veterinary,General Biochemistry, Genetics and Molecular Biology

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4. Cardioprotective Effects of Erythropoietin in the Reperfused Ischemic Heart