Effects of Chronic Viral Infection on Lymphocyte Populations in Middle-aged Baboons (Papio anubis)

Author:

Willis Erin L1,Eberle Richard2,Wolf Roman F3,White Gary L4,McFarlane Dianne5

Affiliation:

1. Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma

2. Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma

3. Department of Comparative Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; Current Address: Oklahoma City Veterans Administration Health Care System, Oklahoma City, Oklahoma

4. Department of Comparative Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma; Current Address: Primate Consulting, Edmond, Oklahoma

5. Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma;, Email: diannem@okstate.edu

Abstract

Aging of the immune system is characterized by the loss of naïve T-cells, increased inflammation, and immune function impairment. Chronic infection with cytomegalovirus is thought to play a role in age-related changes in immunity. Therefore, to assess the effect of pathogens such as cytomegalovirus on the immune system, we determined lymphocyte populations and inflammatory markers over a 3-y period in captive, middle-age baboons, with various exposure to pathogens and shedding pressure. Groups included SPF (i.e., pathogen-negative; n = 14); large-group, conventionally housed (CONV LG; pathogen- positive; n = 14), and small-group, conventionally housed (CONV SM; pathogen-positive; n = 7). All baboon groups showed a decrease in CD45RA+ CD28+ (i.e., naive) cells over time during middle age, but the rate of decline appeared faster in CONV LG baboons than in the other groups. In addition, the reduction in CD45RA+ CD28+ cells in the CONV LG baboons coincided with higher IgG levels against baboon cytomegalovirus, increased serum cortisol concentration, and a greater inflammatory phenotype. The results of this project support a role for cytomegalovirus infection in immune system alterations in middle-aged baboons.

Publisher

American Association for Laboratory Animal Science

Subject

General Veterinary,General Biochemistry, Genetics and Molecular Biology

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