A Developmental Investigation of Stop-Signal Inhibition

Abstract

Abstract. The present study examined the development of response inhibition in the stop-signal task across child (8-13 years), young-adult (18-22 years), and middle-aged adult (29-47 years) groups through a dissociation of low- and higher-frequency ERP activity. Fifty-one subjects (n = 17 in each group) performed the stop-signal task, which consisted of a visual choice reaction time (RT) task and auditory stop-signals, while EEG was recorded. The original EEG data (0.01-30 Hz) was subsequently filtered to separate slow-wave (0.01-2 Hz) and residual (2-30 Hz) activity. Performance findings revealed that stop-signal reaction time (SSRT) decreased from the child to young-adult group and then showed a small increase in the middle-aged adult group. Original ERPs revealed decreasing N1 and N2 amplitudes and increasing P2 and P3 amplitudes across the scalp with increasing age for successful-stop trials. These developmental effects did not occur in the residual waveforms after removal of slow-wave activity. For failed-stop trials, a response-locked negative component, identified as the error-negativity (Ne), showed an age-related decrease in amplitude across the scalp in the residual, but not the original, waveform. The error-positivity (Pe) increased in amplitude with age in the original data, but this was accounted for by a positive slow-wave (PSW). Together, the findings suggest that underlying slow-wave activity accounts for a large number of developmental effects in the traditionally quantified ERP components, but may also obscure effects occurring in residual activity. These findings highlight the importance of dissociating low- and higher-frequency ERP activity in developmental research.