Residual Brain Processing in the Vegetative State

Abstract

Vegetative state (VS) is a clinical condition in the severely brain damaged, characterized by wakefulness but unaccompanied by any evidence of awareness of self or environment, voluntary or purposeful behavioral responses to external stimuli, and communication. A metabolic dysfunction of the frontal-parietal network is thought to be responsible for the “functional disconnection” underlying it. Most subjects recover with or without residual disabilities depending on the extent of brain damage. However, VS persists for over 1 year in about 15% of all cases, with exceptional later recovery; prolonged observation has thus become possible and our perspectives have expanded substantially. In recent years, brain activation in response to painful or emotional stimuli (e.g., the mother’s voice or presence) or under stimulus conditions implying processing at varying levels of functional complexity (including learning and semantic functions) has been documented in unambiguously diagnosed VS subjects by advanced electrophysiological and neuroimaging techniques. Methods, experimental conditions, and the results of studies published in years 2002–2008 are summarized. The extent to which brain activation concomitant to external events reflect brain function remains to be investigated. Today, VS nevertheless appears neither static nor homogeneous. An updated characterization also taking the evidence of residual brain responsiveness into account is due. Research with advanced technologies and sophisticated paradigms of brain activation in VS may help us to understand the basic neural processes underlying human consciousness.