Impairment of Brain Plasticity by Brain Inflammation

Abstract

Abstract. The ability to learn and the ability to reshape brain circuits are regarded as some of the most remarkable and important features of the brain. This ability declines with age due to largely unknown reasons, and it also is altered following stroke. Brain aging is associated with a progressive increase of the levels of inflammatory cytokine in the brain. Likewise, stroke causes pronounced increases of inflammatory cytokines in the brain. Following stroke, plasticity of the cortical representation following sensory deprivation and visualized with [14C]-2-deoxyglucose autoradiography is impaired for several weeks. Likewise, plasticity of visual acuity induced by occlusion of the ipsilateral eye is impaired. Both forms of plasticity may be rescued by treatment with anti-inflammatory drugs. In contrast to this, ocular dominance plasticity which is also induced by visual occlusion is not rescued by this intervention, neither following stroke nor in aged brains. Antiinflammatory interventions may therefore be a useful tool to enhance brain plasticity following stroke, but need to be supplemented by additional strategies to enhance brain plasticity.