Electrodermal Responsiveness and Negative Symptoms in Brain Injured Patients

Abstract

Abstract Electrodermal non-responsiveness has been associated with negative symptoms, especially among schizophrenic patients. The aim of this study was to examine how electrodermal non-response, defined as failure to elicit a skin conductance orienting response to a neutral auditory stimulus, was related to negative symptoms in patients with acquired brain injury. Sixty-four brain injured patients were assessed for apathy, lack of initiative, and emotional indifference. We found that EDA non-responders displayed significantly higher scores on rating scales used to assess apathy and related negative symptoms compared to EDA responders. No such differences were found regarding depressed mood/emotional distress or vegetative symptoms of depression. This difference could not be attributed to neurological etiology nor to localization of lesion. These findings, resembling psychophysiological findings in schizophrenia, indicate that EDA non-response is associated with apathy and related negative symptoms also in brain injured patients. This may also enable a better differentiation between negative symptoms of organic origin and emotional changes related to psychogenic factors after acquired brain damage.