Using a Systems-Based Risk Score Approach to Examine Genetic Predisposition to Novelty Seeking-Reference-Cited by-同舟云学术

Using a Systems-Based Risk Score Approach to Examine Genetic Predisposition to Novelty Seeking

Published:2017-07 Issue:3 Volume:38 Page:163-174
ISSN:1614-0001
Container-title:Journal of Individual Differences
language:en
Short-container-title:Journal of Individual Differences

Author:

Conner Bradley T.¹,Hellemann Gerhard S.²,Demianczyk Abigail C.³,Ritchie Terry⁴,Noble Ernest P.⁴

Affiliation:

1. Department of Psychology, Colorado State University, Fort Collins, CO, USA

2. Biostatistics Core, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, CA, USA

3. Department of Psychology, Temple University, Philadelphia, PA, USA

4. Alcohol Research Center, Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, CA, USA

Abstract

Abstract. Previous research is mixed regarding the relation between dopamine and Novelty Seeking. The goals of the current study were to support the hypotheses that Novelty Seeking is associated with dopamine genes and that modeling genetic risk score increases the utility of genetic information in hypothesis-driven research. The results showed that higher hypodopaminergic genetic risk score positively predicted higher Novelty Seeking score, F(1, 115) = 5.76, p < .01, R2 = 0.06. The findings support study hypotheses and, in combination with previous studies, show the utility of empirically validated system-based risk scores as a means of modeling genetic predisposition in neurobiological systems. This approach provides a mechanism for incorporating genetic predisposition into theory-driven multivariate etiological models of psychological constructs such as personality and mental illness.

Publisher

Hogrefe Publishing Group

Subject

Biological Psychiatry,General Psychology

Link

https://econtent.hogrefe.com/doi/pdf/10.1027/1614-0001/a000233

Reference55 articles.

1. Polygenic Risk Score Improves Prostate Cancer Risk Prediction: Results from the Stockholm-1 Cohort Study

2. Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking

3. Genetic Addiction Risk Score (GARS): Testing For Polygenetic Predisposition and Risk to Reward Deficiency Syndrome (RDS)

4. The Dopamine D4 Receptor (DRD4) Exon 3 VNTR Contributes to Adaptive Personality Differences in an Italian Small Island Population