Carboxylic Derivatives of Vitamin K2 Inhibit Hepatocellular Carcinoma Cell Growth through Caspase/Transglutaminase-Related Signaling Pathways

Author:

QIN Xian-Yang1,FUJII Shinya23,SHIMIZU Akitaka2,KAGECHIKA Hiroyuki2,KOJIMA Soichi1

Affiliation:

1. Micro-Signaling Regulation Technology Unit, RIKEN Center for Life Science Technologies

2. Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University

3. Institute of Molecular and Cellular Biosciences, The University of Tokyo

Publisher

Center for Academic Publications Japan

Subject

Nutrition and Dietetics,Medicine (miscellaneous)

Reference29 articles.

1. 1) El-Serag HB. 2012. Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology 142: 1264-1273.

2. 2) Zeng H, Zheng R, Guo Y, Zhang S, Zou X, Wang N, Zhang L, Tang J, Chen J, Wei K, Huang S, Wang J, Yu L, Zhao D, Song G, Chen J, Shen Y, Yang X, Gu X, Jin F, Li Q, Li Y, Ge H, Zhu F, Dong J, Guo G, Wu M, Du L, Sun X, He Y, Coleman MP, Baade P, Chen W, Yu XQ. 2014. Cancer survival in China, 2003-2005: A population-based study. Int J Cancer 136: 1921-1930.

3. 3) Steward WP, Brown K. 2013. Cancer chemoprevention: a rapidly evolving field. Br J Cancer 109: 1-7.

4. 4) Kakizoe T. 2003. Chemoprevention of cancer—focusing on clinical trials. Jpn J Clin Oncol 33: 421-442.

5. 5) Okita K, Izumi N, Ikeda K, Osaki Y, Numata K, Ikeda M, Kokudo N, Imanaka K, Nishiguchi S, Kondo S, Nishigaki Y, Shiomi S, Ueshima K, Isoda N, Karino Y, Kudo M, Tanaka K, Kaneko S, Moriwaki H, Makuuchi M, Okusaka T, Hayashi N, Ohashi Y, Kumada H; The Peretinoin Study Group. 2014. Survey of survival among patients with hepatitis C virus-related hepatocellular carcinoma treated with peretinoin, an acyclic retinoid, after the completion of a randomized, placebo-controlled trial. J Gastroenterol 50: 667-674.

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