Co-localization of the PDGFβ-Receptor and Actin during PDGF Stimulation in Mouse Fibroblasts

Author:

Moes Maarten J. A.1,Zhou Yeping1,Boonstra Johannes1

Affiliation:

1. Cell Biology, Department of Biology, Institute of Biomembranes, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands

Abstract

The subcellular localization of the PDGFβ-receptor was investigated in relation with PDGF-induced actin and membrane dynamics in mouse C3H10T1/2 fibroblasts. Serum-starved cells exhibit a nonhomogenous distribution of PDGFβ-receptors. However, the observed pattern does not resemble the localization of PDGF-induced actin structures. Interestingly, the PDGFβ-receptor showed a changed subcellular distribution in relation to the formation of PDGF-BB-induced actin structures. Upon PDGF exposure, PDGFβ-receptors were found to accumulate in dorsal circular ruffles. The presence of both macropinosomes and clathrin in the induced circular ruffles suggests that the accumulation of PDGFβ-receptors in circular ruffles results in the efficient internalization of PDGFβ-receptors.

Funder

Dutch Space Organization

Publisher

Hindawi Limited

Subject

General Medicine

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