In SilicoStudies on Fungal Metabolite against Skin Cancer Protein (4,5-Diarylisoxazole HSP90 Chaperone)

Abstract

This work was to find out the dominant secondary metabolites derived from the fungusTrichodermaand to test them against skin cancer protein. The metabolites were extracted in 80% methanol from the fungal biomass ofTrichodermaisolated from mangrove sediment. The crude methanol extract was purified and analysed for the secondary metabolites by GC-MS. Three predominant compounds (heptadecanoic acid, 16 methyl-, methyl ester; 9,12-octadecadienoic acid; cis-9-octadecenoic acid) identified in the extracts were screened against the skin cancer protein (Hsp90) byin-silicodocking method. Of the compounds, heptadecanoic acid, 16 methyl, methyl ester was the most potent having the docking score of  Kcal/mol. This value was better than the standard drug “dyclonine”. This work recommends the heptadecanoic acid, 16 methyl, methyl ester for furtherin vitroandin vivostudies towards its development as anticancer drug.