Impact of Eighteen-Year Varied Compliance to Onchocerciasis Treatment with Ivermectin in Sentinel Savannah Agrarian Communities in Kaduna State of Nigeria

Author:

Osue Hudu O.1,Inabo Helen I.2,Yakubu Sabo E.2,Audu Patrick A.3,Galadima Musa4,Odama Lillian E.5,Musa Danjuma1,Ado Saleh A.2,Mamman Mohammed1

Affiliation:

1. Nigeria Institute for Trypanosomiasis Research (NITR), P. M. B. 2077, Kaduna 800001, Nigeria

2. Department of Microbiology, Faculty of Science, Ahmadu Bello University (ABU), Zaria, Kaduna State, Nigeria

3. Department of Biological Sciences, ABU, Zaria, Kaduna State 810000, Nigeria

4. Department of Microbiology, Faculty of Science, Federal University of Technology, Minna, Niger State 920001, Nigeria

5. National Institute for Pharmaceutical Research and Development (NIPRD), Idun, Abuja 900102, Nigeria

Abstract

Baseline and impact assessment data were generated in 1994 (n=532) and 2011 (n=593) from 6 sentinel villages with generalized onchocerciasis. Only volunteers and a cohort (n=445,75%) were screened at both visits. Each village had received 11 (64.7%) annual treatments and 92.6%, range 88.7–100%, treatment compliance. Overall mean number of treatment was 2.9 ± 1.6 with a range 2.0 ± 1.2–3.3 ± 0.6. Significant decreases in skin microfilaria prevalence from 201 (38%) to 0 (0%), palpable nodule from 77 (15%) to 4 (0.7%), dermal changes from 51 (9.6%) to 2 (0.04%), optic nerve disease from 24 (4.5%) to 4 (2.0%), and onchocercal inducible ocular lesions from 31 (5.8%) to 12 (2.0%) were recorded, P<0.05, (t-test of unpaired data). Cases of glaucoma, 8 (1.4%), and blindness, 6 (1.05%), remained unchanged. Visual acuity ≥6/24 in one or both eyes, 198 (33.45%); cataract, 169 (28.5%); pterygium 157 (26.5%); and acute senilis, 165 (27.9%), were significantly increased and positively correlated with increase in age (R2=0.8980.949). Dissected parous Simulium damnosum caught (n=222) were without infective third stage larva. Active onchocerciasis transmission seems halted despite varied compliance to long-term ivermectin treatment. We recommend continued surveillance and targeted treatment of controlled and hypoendemic areas.

Funder

Nigerian Institute for Trypanosomiasis

Publisher

Hindawi Limited

Subject

General Earth and Planetary Sciences,General Environmental Science

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3