Affiliation:
1. Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan
2. Department of Pharmaceutical Sciences, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan
Abstract
A series of eighteen 1,3,4-oxadiazole derivatives have been synthesized by treating aromatic acid hydrazides with carbon disulfide in ethanolic potassium hydroxide yielding potassium salts of 1,3,4-oxadiazoles. Upon neutralization with 1 N hydrochloric acid yielded crude crystals of 1,3,4-oxadiazoles, which were purified by recrystallization in boiling methanol. The synthesized 1,3,4-oxadiazoles derivatives were evaluatedin vitrofor their urease inhibitory activities, most of the investigated compounds were potent inhibitors ofJack beanurease. The molecular docking studies were performed by docking them into the crystal structure ofJack beanurease to observe the mode of interaction of synthesized compounds. The synthesized compounds were also tested for antibacterial and antioxidant activities and some derivatives exhibited very promising results.
Funder
Higher Education Commission, Pakistan
Cited by
50 articles.
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