Stability-Indicating HPTLC-Densitometric Method for Estimation of Dorzolamide Hydrochloride in Eye Drops-Reference-Cited by-同舟云学术

Stability-Indicating HPTLC-Densitometric Method for Estimation of Dorzolamide Hydrochloride in Eye Drops

Published:2012-09-04 Issue: Volume:2012 Page:1-7
ISSN:2090-732X
Container-title:ISRN Analytical Chemistry
language:en
Short-container-title:ISRN Analytical Chemistry

Author:

Havele S. S.¹,Dhaneshwar S. R.²

Affiliation:

1. Department of Pharmaceutical Chemistry, Poona College of Pharmacy, Bharati Vidyapeeth University, Maharashtra, Pune 411038, India

2. Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, , , RAK Medical & Health Sciences University, P.O. Box 11172, Ras Al-Khaimah, UAE

Abstract

The present study describes the degradation of dorzolamide HCl under different International Conference on Harmonization prescribed stress conditions (hydrolysis, oxidation, thermolysis, and photolysis) and application of a specific and selective stability-indicating chromatography assay. HPTLC was done on silica Gel 60 F254 TLC plate using chloroform: methanol in the ratio of 9.0 : 1.0 (v/v) as mobile phase and detection at 253 nm.

Publisher

Hindawi Limited

Subject

General Medicine

Link

http://downloads.hindawi.com/archive/2012/414075.pdf

Reference15 articles.

1. Low level determination of dorzolamide and its de-ethylated metabolite in human plasma by liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry

2. Rapid high-performance liquid chromatographic assay of dorzolamide in rabbit aqueous humor

3. Ultratrace analysis of drugs in biological fluids using affinity probe capillary electrophoresis: Analysis of dorzolamide with fluorescently labeled carbonic anhydrase

4. Simultaneous quantification of carteolol and dorzolamide in rabbit aqueous humor and ciliary body by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry

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