Thio Analogs of Pyrimidine Bases: Synthesis, Spectroscopic Study, and In Silico Biological Activity Evaluation of New 2-o-(m- and p-)Chlorobenzylthio-6-Methyl-5-Piperidino-(Morpholino-)Methyluracils-Reference-Cited by-同舟云学术

Thio Analogs of Pyrimidine Bases: Synthesis, Spectroscopic Study, and In Silico Biological Activity Evaluation of New 2-o-(m- and p-)Chlorobenzylthio-6-Methyl-5-Piperidino-(Morpholino-)Methyluracils

Published:2011-04-07 Issue: Volume:2011 Page:1-6
ISSN:2090-5149
Container-title:ISRN Organic Chemistry
language:en
Short-container-title:ISRN Organic Chemistry

Author:

Pospieszny Tomasz¹,Szymankiewicz Marcin¹,Wyrzykiewicz Elżbieta¹

Affiliation:

1. Faculty of Chemistry, Adam Mickiewicz University in Poznań, Grunwaldzka 6, 60-780 Poznań, Poland

Abstract

Six new 2--(- and -)chlorobenzylthio-6-methyl-5-piperidino-(or morpholino-) methyluracils have been prepared. The structures of these compounds were confirmed by spectroscopic (FT-IR, UV-Vis, NMR, NMR, and HMBC) and elemental analyses. Estimation of pharmacotherapeutic potential has been made for synthesized compounds on the basis of prediction of activity spectra for substances (PASS).

Publisher

Hindawi Limited

Subject

General Medicine

Link

http://downloads.hindawi.com/archive/2011/610521.pdf

Reference16 articles.

1. Synthesis and Antiviral Activity of 6-Benzyl Analogs of 1-[(2-Hydroxyethoxy)methyl]-5-(phenylthio)thymine (HEPT) as Potent and Selective Anti-HIV-1 Agents

2. Die Rolle der Chemie in der Entwicklung einer Krebstherapie durch die Bor-Neutroneneinfangreaktion

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