Bio301: A Web-Based EST Annotation Pipeline That Facilitates Functional Comparison Studies-Reference-Cited by-同舟云学术

Bio301: A Web-Based EST Annotation Pipeline That Facilitates Functional Comparison Studies

Published:2012-11-22 Issue: Volume:2012 Page:1-5
ISSN:2090-7346
Container-title:ISRN Bioinformatics
language:en
Short-container-title:ISRN Bioinformatics

Author:

Chen Yen-Chen¹,Chen Yun-Ching²,Lin Wen-Dar³,Hsiao Chung-Der⁴,Chiu Hung-Wen⁵,Ho Jan-Ming¹

Affiliation:

1. Institute of Information Science, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 115, Taiwan

2. Department of Biomedical Engineering, The Whitaker Biomedical Engineering Institute at Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA

3. Institute of Plant and Microbial Biology, Academia Sinica, 128 Academia Road, Section 2, Nankang, Taipei 115, Taiwan

4. Department of Bioscience Technology, Chung Yuan Christian University, 200 Chung Pei Road, Chung Li City 32073, Taiwan

5. Graduate Institute of Biomedical Informatics, Taipei Medical University, 250 Wu-Hsing Street, Taipei City 110, Taiwan

Abstract

In this postgenomic era, a huge volume of information derived from expressed sequence tags (ESTs) has been constructed for functional description of gene expression profiles. Comparative studies have become more and more important to researchers of biology. In order to facilitate these comparative studies, we have constructed a user-friendly EST annotation pipeline with comparison tools on an integrated EST service website, Bio301. Bio301 includes regular EST preprocessing, BLAST similarity search, gene ontology (GO) annotation, statistics reporting, a graphical GO browsing interface, and microarray probe selection tools. In addition, Bio301 is equipped with statistical library comparison functions using multiple EST libraries based on GO annotations for mining meaningful biological information.

Funder

National Science Council

Publisher

Hindawi Limited

Subject

General Earth and Planetary Sciences,General Engineering,General Environmental Science

Link

http://downloads.hindawi.com/archive/2012/139842.pdf

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