Conformational Analysis in 18-Membered Macrolactones Based on Molecular Modeling-Reference-Cited by-同舟云学术

Conformational Analysis in 18-Membered Macrolactones Based on Molecular Modeling

Published:2011-04-19 Issue: Volume:2011 Page:1-5
ISSN:2090-5149
Container-title:ISRN Organic Chemistry
language:en
Short-container-title:ISRN Organic Chemistry

Author:

Belaidi Salah¹^ORCID,Harkati Dalal¹^ORCID

Affiliation:

1. Department of chemistry, Faculty of sciences, University of Biskra, BP 145, 07000 Biskra, Algeria

Abstract

Conformational analysis of 18-ring membered macrolactones has been carried out using molecular mechanics calculations and molecular dynamics. A high conformational flexibility of macrolactones was obtained, and an important stereoselectivity was observed for the complexed macrolides. For 18d macrolactone, which was presented by a most favored conformer with 20.1% without complex, it was populated with 50.1% in presence of Fe(CO)3.

Publisher

Hindawi Limited

Subject

General Medicine

Link

http://downloads.hindawi.com/archive/2011/594242.pdf

Reference20 articles.

1. Spirastrellolide B Reveals the Absolute Configuration of the Spirastrellolide Macrolide Core

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