Antimicrobial Susceptibility Pattern of Escherichia Coli Isolated From Urine Specimen of Urinary Tract Infection Patients

Abstract

The present study is designed to assess the development of E coli resistance against different antibiotics and to determine their antimicrobial susceptibility pattern. METHODOLOGY: This cross sectional study shows antimicrobial susceptibility of 100 isolates of Escherichia coli (E coli) from urine samples of urinary tract infection (UTI) patients. The samples were cultured on CLED agar, and susceptibility checked with 24 antimicrobial drugs by Disc Diffusion Method. RESULTS: UTI due to E coli was more frequent in females (67%) compared to males (33%). The antibiotic susceptibility pattern was Amikacin (92.9%), Chloramphenicol (83.8%), Colistin (82%), Ertapenem (95.2%), Fosfomycin (98.2%), Gentamycin (91%), Imipenem (94.6%), Meropenem (95.2%), Piperacillin (98.8%), Tigecyline (97.6%), Ceftazidime (53.9%). E coli showed resistance to the remaining 12 antibiotics including Moxifloxacin (68.3%), Cefobid (56.8%), Maxipime (61.7%), Levofloxacin (72.5%), Cotrimoxazole (64.7%), Co-amoxiclav (68.9%), Ciprofloxacin (71.3%), Cefuroxime (59.3%), Ceftriaxone (70.1%), Cefpirome (57.5%), Cefepime (59.3%) and Aztreonam (55.1%). CONCLUSION: These findings suggest that UTI due to E coli is more common in females than males and the bacterium showed highest sensitivity to Piperacillin and Fosfomycin and highest resistivity to Levofloxacin and Ciprofloxacin.