Abstract
CYP2A6 enzyme is an enzyme that is responsible for the metabolism of nicotine into cotinine. Meanwhile, glutathione is a tripeptide -L-glutamyl-L-cysteineyl-glycine, which has high concentrations in the liver. This literature review study aims to determine the effect of giving foods rich in CYP2A6 enzymes and glutathione to reduce nicotine levels in the body of smokers. The inclusion criteria used were the year of publication of articles from the last 5 years, discussing the effect of food doses with CYP2A6 enzymes and glutathione on reducing nicotine levels, experimental research methods, and full-text journals that can be accessed free of charge. The data source comes from Pubmed and Writing a Literature Review began in May to June 2022. Based on the results of 4 literature review articles, it was found that there was an effect of feeding with CYP2A6 enzymes and glutathione on reducing nicotine levels in smokers.