A Review of Wound Healing Mechanisms of Natural Products in Keratinocyte Cells

Abstract

Background: Wound-healing in the skin is one mechanism that maintains homeostasis. Ineffective skin wound healing is a significant health problem that ultimately causes morbidity and mortality. The process of wound healing using traditional medicine has a good effect with various mechanisms of action. This review aims to provide insights related to the wound-healing mechanisms of several plants in HaCat cells. Methods: The literature study method was used from primary and secondary libraries. The library search was conducted using online-based library search instruments from 1988 to 2021, such as NCBI-PubMed, Google Scholar, and Elsevier. Results: The wound-healing mechanism includes processes that restore skin integrity through four stages: hemostasis, inflammation, multiplication, and remodeling. Many plants have been studied to have activity in wound healing by various mechanisms. Conclusions: Several compounds in plants have shown the activity in wound healing in keratinocyte cells  by various mechanisms.