Case Report: The effect of bone morphogenetic proteins (BMP) in comparison with a xenograft in the management of mandibular bone defects

Abstract

Background This study aims to compare the effect of Bone Morphogenetic Proteins (rhBMP), carried on a gelatin sponge scaffold in comparison with the Xenograft BioOss® in the management of mandibular bone defects. Case presentation The case is a 48-year-old woman who had 2 cysts in the mandibular bone, BMP2 was placed within the first hole with a gelatin sponge, and a BioOss® graft was placed within the second defect. The radiographic evaluation was conducted before and after surgery and 1, 3, and 6 months after the surgical work. Histological assessment was conducted after 6 months of the surgical work. Results The results of the radiographic evaluation found that there was no big difference between the healing in the holes filled with rhBMP2 with gelatin sponge and the healing in the holes filled with BioOss®. Conclusion The use of a gelatin sponge impregnated with Bone Morphogenetic Proteins improves and accelerates the healing of bone defects and is comparable to the effectiveness of using a BioOss® graft.