Pathomechanisms Of Non-Coding RNAs, Hub Genes, and Lifestyle Related To The Oxidative Stress In Type 2 Diabetes And Cardiac Complications.

Author:

Hajibabaie Fatemeh,Aali Faranak,Abedpoor NavidORCID

Abstract

Cytokine storms, oxidative stress, and hyperglycemia can enhance the risk of type 2 diabetes (T2D). Moreover, T2D may change the functional and structural heart. However, some signaling pathways, such as insulin resistance, dyslipidemia, and hyperglycemia, can play in T2D, and various pathomechanics and pathophysiology involved in T2D are not understood. Moreover, it is well documented that the non-coding RNAs are potentially pivotal molecules in oxidative stress, inflammation, and cell death signaling pathways. Hence, long non-coding RNAs (lncRNAs) and microRNAs may have vital roles in oxidative stress, inflammation, metabolism, T2D, and cardiovascular systems. Non-coding RNAs can target hub gene networks and suppress or trigger various cascades. Furthermore, lifestyle is the other factor that may affect the prevalence of T2D. A sedentary lifestyle and excessive sitting can enhance inflammation, oxidative stress, and hyperglycemia. Here, we attempt to comprehend the role of hub genes, non-coding RNAs, and unhealthy lifestyles on the pathomechanics and pathophysiology of diabetic vascular complications.

Publisher

F1000 Research Ltd

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference92 articles.

1. Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links.;O Oguntibeju;Int. J. Physiol. Pathophysiol. Pharmacol.,2019

2. MicroRNAs and oxidative stress: an intriguing crosstalk to be exploited in the management of type 2 diabetes.;T Vezza;Antioxidants.,2021

3. Role of Ayurveda in the management of Non-Communicable Disease.;M Gupta;J. Ayurveda Integr. Med. Sci.,2022

4. IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045.;N Cho;Diabetes Res. Clin. Pract.,2018

5. Genetics of diabetes mellitus and diabetes complications.;J Cole;Nat. Rev. Nephrol.,2020

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3