PD-L1 expression as predictor of immunotherapy eligibility in penile squamous cell carcinoma patients

Author:

Haritsyah Warli MuhammadORCID,Prapiska Fauriski Febrian,Siregar Ginanda Putra,Sihombing Bungaran,Warli Syah Mirsya

Abstract

Background: Penile cancer is a rare malignancy and potentially lethal disease with an incidence of 0,6-2,1 per 100.000. Squamous cell carcinoma (SqCC) is the most commonly found penile malignancy. PD-L1 is a tumor marker that co-stimulates the receptor PD-1 to suppress T-cell-mediated antitumor immunity. Methods: This study is a retrospective cohort study with a total sampling method. The slides taken from the biopsies of seventy-six male patients from Haji Adam Malik Hospital diagnosed with penile squamous cell carcinoma who have already undergone penile biopsy were re-examined for this study, and PD-L1 levels were measured accordingly. Statistical methods were used to assess the association between PD-L1 levels and with SqCC stage. Results: A total of 76 male patients are the subjects of this study. PD-L1 positivity is identified in 25 patients with +1 intensity in 10 patients (13,2%), +2 in 7 patients (9,2) and +3 intensity in 8 patients (10,5%). There are 36 patients (47,4%) diagnosed with stage T3 SqCC, 35 patients (46,1%) with stage N2 SqCC, and 10 patients (13,2%) with stage M1 SqCC. There is significant correlation between PD-L1 expression and metastasis (p=0,022). However, there is no significant correlation between PD-L1 expression and stage N tumor (p=0,167). Conclusions: PD-L1 highly expressed in advanced stage penile SqCC (32.9%), which is associated with the high-risk clinicopathologic features and poor clinical outcomes. These findings showed a potential usage of immunotherapy in advanced penile SqCC treatment.

Publisher

F1000 Research Ltd

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference31 articles.

1. Incidence of penile cancer worldwide: systematic review and meta-analysis.;C Montes Cardona;Rev. Panam. Salud Publica.,2017

2. Incidence trends in primary malignant penile cancer.;J Barnholtz-Sloan;Urol. Oncol.,2007

3. Contemporary management of penile cancer: greater than 15 year MSKCC experience.;K Moses;Can. J. Urol.,2014

4. Management of penile cancer.;G Diorio;Urology.,2016

5. Identifying the needs of penile cancer sufferers: a systematic review of the quality of life, psychosexual and psychosocial literature in penile cancer.;S Maddineni;BMC Urol.,2009

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