Predicting systemic lupus erithematosus disease activity index 2000 (Sledai 2k) score after pulse dose metyl prednisolone in severe systemic lupus erithematosus

Author:

Paramaiswari Ayu,Kertia Nyoman,Intansari Umi,Nugroho Dhite BayuORCID

Abstract

Background: Systemic lupus erythematosus (SLE) is a chronic multisystem rheumatic disease characterized by developing autoantibodies against nucleus antigen. It has a broad range of clinical symptoms and the potential to affect nearly all organs and tissues. Pulse dosage methylprednisolone (MEP) is the immunosuppression modality for life-threatening or organ-threatening SLE. However, it is challenging to estimate the MEP response rate. We combine clinical symptoms, routine laboratory examinations, and more specific protein examinations such as soluble B-cell activating factor (sBAFF), B-cell activating factor receptor (BAFF-R), and Interferon gamma-induced protein 10 (IP-10) to develop a formula that can predict the SLE Disease Activity Index 2K (SLEDAI 2K) score following a pulse dosage of methylprednisolone. Methods: In a prospective cohort study, patients with severe SLE with a SLEDAI 2K score of 12 or Lupus nephritis class III or IV according to WHO criteria were given methylprednisolone 500 mg/day for three consecutive days. Enzyme-linked immunosorbent assay (ELISA) tested blood samples for soluble (s) BAFF, IP 10, and flow cytometry for BAFF-R, CD-19. The SLEDAI 2K score was reevaluated after a pulse dose of methylprednisolone was administered. All statistical analyses were conducted using the Rstudio program. Results: Overall, 80 patients were included. Multivariate multiple regression analysis revealed that urine protein creatinine ratio (UPCR) (x1), CD19 percentage (x2), serum BAFF (x3), vasculitis (x4), and rash (x5) taken before MEP pulse were predictors for SLEDAI 2k score after pulse dose methylprednisolone in severe SLE with the formula 13.41+ (0.0008542 * x1) + -0.1829338  * x2) + (0.0008776  *  x3) + (7.1801728  * x4) + (7.5429676  * x6). Conclusions: Formula to predict SLEDAI 2k score after MEP pulse was 13.41+ (0.0008542 * x1) + -0.1829338  * x2) + (0.0008776  *  x3) + (7.1801728  * x4) + (7.5429676  * x6). Further validation is needed to be used in clinical practice.

Publisher

F1000 Research Ltd

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3