Case Report: The application of sildenafil citrate treatment on cervical tuberculosis patient seeking IVF treatment

Abstract

This case report describes the application of sildenafil citrate treatment in a cervical tuberculosis (TB) patient seeking in vitro fertilization (IVF) treatment. The patient, a 34-year-old female with a history of cervical TB and primary infertility, underwent anti-TB treatment before fertility treatment. Cervical stenosis and a thin endometrium were identified during a transvaginal ultrasound, posing challenges to successful IVF outcomes. Sildenafil citrate, a phosphodiesterase-5 (PDE-5) inhibitor known to improve endometrial blood flow, was administered orally at a dosage of 50 mg, three times daily, starting on the fifth day of the menstrual cycle. The patient exhibited an increase in endometrial thickness, indicating improved receptivity. Clinical pregnancy was achieved. These findings suggest that sildenafil citrate may have the potential as an adjunct therapy to enhance IVF success in cervical TB patients, although further research is needed to validate these results in larger studies.