Comparison of rheumatoid arthritis factors, adenosine deaminases and uric acid in arthritis and non-arthritis patients: A protocol

Abstract

Rheumatic disorders are viewed as a public health issue because they affect thousands of individuals around the world and increase health care expenses. Numerous biochemical markers may play a role in the pathophysiology and etiology of rheumatoid arthritis  (RA) due to its local as well as systemic inflammatory effects. Rheumatoid factors (RF) can be found in a variety of people, including young, healthy people, the elderly, and people with RA. In this study we will assess and compare the occurrence, clinical presentation, effects and possible risk of biochemical parameters such as uric acid, adenosine deaminase (ADA,), RA factor between arthritis patients and non - arthritis patients. A total of 82 participants — 41 RA patients and 41 healthy controls (non-arthritis patients) —will be included in the study. The levels of serum ADA, uric acid, and rheumatoid factor will be examined, and independent tests will be used for the statistical analysis. Serum ADA rheumatoid factors levels in RA patients is higher in healthy control.  When comparing the uric acid levels of RA patients with healthy controls, there is no significant change in the uric acid level. The degree underlying ADA activity between RA patients and healthy individuals should differ noticeably, confirming the test’s value in the diagnosis of the condition.