Abstract
The interferon response protects cells from invading viral pathogens by transcriptionally inducing the expression of interferon-stimulated genes (ISGs), some of which encode effectors with varied antiviral functions. As screening technologies improve and mouse model development quickens, more ISGs are continually being identified, characterized mechanistically, and evaluated for protective rolesin vivo. This review highlights selected recent findings of ISG effectors that contribute to our understanding of the interferon antiviral response.
Funder
National Institute of Allergy and Infectious Diseases
Rita Allen Foundation
Subject
General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine