A cross-sectional study approach towards management of ovarian tumour by frozen section at laparotomy and assessing its validity by gold standards of histopathology

Abstract

Background Ovarian tumours represent a complex clinical challenge, requiring accurate diagnosis to guide appropriate surgical management. This study protocol outlines a cross-sectional investigation to evaluate the diagnostic accuracy of frozen section analysis during laparotomy for ovarian tumours, comparing it with the gold standard of histopathology. Methods The study will be conducted over two years (2022-2024) at the Department of Obstetrics and Gynaecology, Acharya Vinoba Bhave Rural Hospital (AVBRH), Wardha, India. Fifty eligible patients with ovarian masses will be included, with data collected through comprehensive demographic and clinical assessments, ultrasonography, and computed tomography scans. Frozen section analysis will be performed during staging laparotomy, and diagnoses will be compared with final paraffin-embedded histopathological results. Statistical analyses will be conducted to assess diagnostic accuracy, including sensitivity, specificity, positive predictive value, and negative predictive value. Expected outcomes The study aims to provide insights into the effectiveness of frozen section analysis as a real-time diagnostic tool for ovarian tumours, with implications for surgical decision-making. The results will be presented in peer-reviewed journals and conferences, enhancing clinical practice in gynecologic oncology.