Prediction of the effectiveness of COVID-19 vaccine candidates-Reference-Cited by-同舟云学术

Prediction of the effectiveness of COVID-19 vaccine candidates

Published:2020-05-14 Issue: Volume:9 Page:365
ISSN:2046-1402
Container-title:F1000Research
language:en
Short-container-title:F1000Res

Author:

Veljkovic Veljko^ORCID,Perovic Vladimir,Paessler Slobodan

Abstract

A safe and effective vaccine is urgently needed to bring the current SARS-CoV-2 pandemic under control. The spike protein (SP) of SARS-CoV-2 represents the principal target for most vaccines currently under development. This protein is highly conserved indicating that vaccine based on this antigen will be efficient against all currently circulating SARS-CoV-2 strains. The present analysis of SP suggests that mutation D614G could significantly decrease the effectiveness of the COVID-19 vaccine through modulation of the interaction between SARS-CoV-2 and its principal receptor ACE2.

Publisher

F1000 Research Ltd

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

https://f1000research.com/articles/9-365/v1/pdf

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