Predicting the chances of live birth for couples undergoing IVF-ICSI: a novel instrument to advise patients and physicians before treatment

Author:

Estácio da Veiga BrunaORCID,Brás de Guimarães Beatriz,Tavares Duarte PedroORCID,Metello José Luis,Ferreira Fernando,Ferreira Pedro,Fonseca José Manuel

Abstract

Background: The prevalence of infertility ranges from 3.5% to 16.7% in more developed countries. For this reason, the number of In Vitro Fertilization(IVF)  technique and Intracytoplasmic Sperm Injection (ICSI) treatments has been significantly increasing. Several factors affect the success rate of in vitro treatments, which can be used to calculate the probability of success for each couple. As these treatments are complicated, expensive and with a variable probability of success, the most common question asked by IVF patients is “What are my chances of conceiving before starting an IVF/ICSI treatment?”. The main aim of this study is to develop a validated model that estimates the chance of a live birth before the start of an IVF/ICSI non-donor cycle. Methods: A logistic regression model was developed based on the retrospective study of 737 IVF/ICSI cycles. Overall 14 pre-treatment variables were evaluated (woman’s and man’s age, duration of infertility, cause of infertility, woman’s and man’s Body Mass Index (BMI), Anti-Müllerian Hormone (AMH), Antral Follicle Count (AFC), woman’s and man’s ethnicity, woman’s and man’s smoking status and woman’s and man’s previous live children) and the outcome of the treatment was discriminated as "live birth" or "no live birth". Results: From the 14 variables acquired before starting the IVF/ICSI procedures, only male factor, man’s BMI, man's mixed ethnicity and level of AMH were statistically significant. The interactions between infertility duration and woman’s age, infertility duration and man’s BMI, AFC and AMH, AFC and woman’s age, AFC and woman’s BMI, and AFC and disovulation were also statistically significant. The Area Under the Receiver Operating Characteristic (AUROC) curve test for the discriminatory ability of the final prediction model was 0.700 (95% Confidence Interval (CI) 0.660–0.741). Conclusions: This model might result in a new validated decision support system to help physicians to manage couples’ pre-treatment expectations.

Funder

Portuguese Foundation for Science and Technology

Publisher

F1000 Research Ltd

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference47 articles.

1. The international glossary on infertility and fertility care, 2017.;F Zegers-Hochschild;Hum Reprod.,2017

2. International estimates of infertility prevalence and treatment-seeking: potential need and demand for infertility medical care.;J Boivin;Hum Reprod.,2007

3. Estudo Afrodite: Caracterização da infertilidade em Portugal (Vol. 1. Estudo na Comunidade).;J Silva-Carvalho;Porto Fac Med da Univ do.,2009

4. Fertility and infertility: Definition and epidemiology.;M Vander Borght;Clin Biochem.,2018

5. Robert Edwards: the path to IVF.;M Johnson;Reprod Biomed Online.,2006

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