Abstract
With the successful production of artemisinic acid in yeast, the promising potential of synthetic biology for natural product biosynthesis is now being realized. The recent total biosynthesis of opioids in microbes is considered to be another landmark in this field. The importance and significance of enzymes in natural product biosynthetic pathways have been re-emphasized by these advancements. Therefore, the characterization and elucidation of enzymatic function in natural product biosynthesis are undoubtedly fundamental for the development of new drugs and the heterologous biosynthesis of active natural products. Here, discoveries regarding enzymatic function in natural product biosynthesis over the past year are briefly reviewed.
Subject
General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine
Reference55 articles.
1. The relevance of higher plants in lead compound discovery programs.;A Kinghorn;J Nat Prod.,2011
2. Bioactive microbial metabolites.;J Bérdy;J Antibiot (Tokyo).,2005
3. Qinghaosu.;T Hien;Lancet.,1993
4. High-level semi-synthetic production of the potent antimalarial artemisinin.;C Paddon;Nature.,2013
5. Stabilizing the antimalarial drug supply: Semisynthetic artemisinin could meet up to one-third of global need,2014
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