Tumour Cell Heterogeneity-Reference-Cited by-同舟云学术

Tumour Cell Heterogeneity

Published:2016-02-29 Issue: Volume:5 Page:238
ISSN:2046-1402
Container-title:F1000Research
language:en
Short-container-title:F1000Res

Author:

Gay Laura,Baker Ann-Marie,Graham Trevor A.

Abstract

The population of cells that make up a cancer are manifestly heterogeneous at the genetic, epigenetic, and phenotypic levels. In this mini-review, we summarise the extent of intra-tumour heterogeneity (ITH) across human malignancies, review the mechanisms that are responsible for generating and maintaining ITH, and discuss the ramifications and opportunities that ITH presents for cancer prognostication and treatment.

Publisher

F1000 Research Ltd

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

https://f1000research.com/articles/5-238/v1/pdf

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