Abstract
The number of controlled human infection models (CHIMs) conducted worldwide has increased considerably in recent years, although few have been conducted in low and middle-income countries (LMICs), where infectious diseases have the greatest burden. Recently Oxford University Clinical Research Unit (OUCRU) in Ho Chi Minh City (HCMC) started developing CHIM research proposals motivated by the need to develop a clearer and more grounded understanding of the issues surrounding the conduct of CHIMs in LMICs. To explore initial perceptions and barriers to conducting CHIMs in Vietnam, OUCRU researchers conducted a set of key stakeholder interviews early in 2018 and held a CHIM workshop in HCMC in March 2018. This paper summarizes the discussions from the workshop and outlines a way forward for conducting CHIMs in Vietnam.
Subject
General Biochemistry, Genetics and Molecular Biology,Medicine (miscellaneous)
Reference35 articles.
1. Controlled human infections: A report from the controlled human infection models workshop, Leiden University Medical Centre 4-6 May 2016.;M Roestenberg;Vaccine.,2017
2. Controlled Human Infection Model Studies. Summary of a workshop held on 6 February 2018,2018
3. Expert Committee on Biological Standardization, Geneva, 17 to 21 October 2016 Human Challenge Trials for Vaccine Development: regulatory considerations Technical Report Series.;WHO Tech Rep Ser.,2016
4. Challenge studies of human volunteers: ethical issues.;T Hope;J Med Ethics.,2004
5. Ethical criteria for human challenge studies in infectious diseases.;B Bambery;Public Health Ethics.,2016
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